What is Orthokine therapy and how is it administered?

The Orthokine therapeutic system is a unique way for treating joint pain as well as tendon, ligament and muscle injuries, without adding drugs or other foreign substances. This treatment method is entirely biological and does not use anything other than your own endogenous proteins and healing factors.

At the beginning of the Orthokine therapy process, the patient’s blood is drawn and processed under special conditions. Thus processed serum, enriched with inflammatory blockers and healing factors, is periodically returned by injections to the patient’s pain-affected area.

The Orthokine therapy has been in use since 1997 and is currently used for the treatment of patients by more than 500 licensed surgeons – orthopedists, physiatrists, neurosurgeons, rheumatologists and sports physicians in the world, with a high success rate. To date, more than 500.000 patients have been treated with Orthokine.

How is it administered?

1. The blood is drawn directly from the vein into a special EOT®II syringe. Glass beads with uneven surfaces within the EOT®II syringe make the blood cells adhere to them and encourage the synthesis of inflammation block proteins and growth factors.

2. EOT®II syringes are placed in an incubator at 37C, for 6-9 hours, which represents optimal conditions for obtaining the substances produced during the physiological healing of injury: 

– inflammation blockers cytokines (e.g. IL-1Ra, IL-10, signal proteins which may restrict the intensity and duration of an inflammation of the tissue and kick-start regeneration) and lipid mediators;

– growth factors and exosoma (stimulate regeneration in the affected tissue).

The totality of these substances comprises Blood Cell Secretome (BCS).

3. Blood cells are separated from serum by centrifugation and the serum enriched with a high concentration of inflammation blocking proteins, lipid mediators, growth factors and exosoma is kept for further use.

4. Finally, we get 5-6 serum injections, which, depending on the indication, are injected 1-2 times a week into the affected joint of another region of the body.